HCID 67957189, compound → Methyl-2-[4-trifluoromethyl-piperidinyl]-4-methylamino-5-amino-benzoate

HRID 1189687Notes

Reaction equation

HRID 1189687 reaction equation
[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[N:15]1[CH2:20][CH2:19][CH:18]([C:21]([F:24])([F:23])[F:22])[CH2:17][CH2:16]1>[Ni].CO>[CH3:1][O:2][C:3](=[O:25])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[N:15]1[CH2:16][CH2:17][CH:18]([C:21]([F:22])([F:24])[F:23])[CH2:19][CH2:20]1

Participants

4

Reactant 1

HCID 67957189HCID 67957189, compound

Product 1

HCID 67957313Methyl-2-[4-trifluoromethyl-piperidinyl]-4-methylamino-5-amino-benzoate

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A mixture of methyl-2-[4-trifluoromethyl-piperidinyl]-4-methylamino-5-nitro-benzoate (1.80 g, 4.19 mmol), Ra—Ni (200 mg) and MeOH (100 mL) is stirred for 5 h under 3 bar H2-atmosphere. The mixture is filtered, and the filtrate is concentrated.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated

Sources & evidence

ORD record
ord-8bb9092817144b45a52ccc97a863ed9e
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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