Sodium Hydroxide → 2-{2,6-Dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-[4-trifluoromethyl-piperidinyl]-1-methyl-1H-benzimidazole-5-carboxylic acid

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Reaction Steps

A mixture of 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-[4-trifluoromethyl-piperidinyl]-1-methyl-1H-benzimidazole-5-carboxylic acid methyl ester (2.54 g, 4.17 mmol), 50% aq NaOH-solution (10.3 ml) and MeOH (41 ml) is stirred for 2.5 h at rt and concentrated. The concentrate is acidified with 4N HCl (to pH ˜6) and the precipitate is filtered, washed with water and dried.

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