HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylcarbodiimide → HCID 178481222, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylcarbodiimide | HCID 12734 | — |
| Reactant | (2,4-Dichloro-3-isothiocyanato-benzyl)-carbamic acid tert-butyl ester | HCID 56840196 | — |
| Reactant | HCID 178482174 | HCID 178482174 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 178481222 | HCID 178481222 | — |
Reaction Steps
The title compound is prepared in analogy to 1e from N-(trans-4-trifluoromethyl-cyclohexyl)-6-[3-aza-bicyclo[3.1.0]hex-1-yl]-4-methylamino-5-amino-benzoic acid amide (3.2 g, 8.0 mmol), (2,4-dichloro-3-isothiocyanato-benzyl)-carbamic acid tert.-butyl ester (compound B; 2.69 g, 8.0 mmol), DIC (1.25 mL) and MeCN (30 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674113B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-d853061a37cc44a38de48e234d874228 |
| Source note | uspto-grants-2014_03 |