Hydrochloric Acid → HCID 178481215, compound

Participants

Reaction Steps

A mixture of N-(trans-4-trifluoromethyl-cyclohexyl)-2-{2,6-dichloro-3-[(tert.-butoxycarbonylamino)-methyl]-phenylamino}-6-[3-aza-bicyclo[3.1.0]hex-1-yl]-1-methyl-1H-benzimidazole-5-carboxylic acid amide (compound 185, 3.3 g, 4.7 mmol), 6 mL 4M HCl in dioxane, 10 mL dioxane and 5 mL 2-propanol is stirred overnight. The resulting precipitate is collected by filtration, diluted with EtOAc and washed with 1N aq NaOH. The organic phase is dried with Na2SO4, filtered and concentrated.

Provenance & Evidence