反应详情

A mixture of 2-{2,6-dichloro-3-[aminomethyl]-phenylamino}-6-[4-trifluoromethyl-piperidinyl]-1-methyl-1H-benzimidazole-5-carboxylic acid ethyl ester (5.83 g, 10 mmol), 50% aq NaOH-solution (25 ml) and MeOH (100 ml) is stirred for 2.5 h at rt. The mixture is concentrated and slowly added to ice-cooled 12 M aq HCl (39.5 mL). Then aq NaHCO3 solution is added (to pH 8) and the resulting precipitate is collected by filtration and dried.

1. concentrationThe mixture is concentrated
2. additionslowly added to ice-
3. temperaturecooled 12 M aq HCl (39.5 mL)
4. additionThen aq NaHCO3 solution is added (to pH 8)
5. filtrationthe resulting precipitate is collected by filtration
6. customdried