8-(2-Fluoro-phenyl)-quinoxaline-5-carboxylic acid [4-(2-dimethylamino-ethoxy)phenyl]-amide → HCID 44515354, compound

HRID 1189762Notes

Reaction equation

HRID 1189762 reaction equation
CN(C)CCOC1C=C[C:9]([NH:12][C:13]([C:15]2[C:16]3[N:17]=[CH:18][CH:19]=[N:20][C:21]=3[C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[F:31])=[CH:23][CH:24]=2)=[O:14])=CC=1>C(Cl)Cl.CO>[NH:17]1[CH:16]=[CH:21][N:20]=[C:9]1[NH:12][C:13]([C:15]1[C:16]2[N:17]=[CH:18][CH:19]=[N:20][C:21]=2[C:22]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[F:31])=[CH:23][CH:24]=1)=[O:14]

Participants

3

Reactant 1

HCID 445153538-(2-Fluoro-phenyl)-quinoxaline-5-carboxylic acid [4-(2-dimethylamino-ethoxy)phenyl]-amide

Product 1

HCID 44515354HCID 44515354, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

The title compound was prepared in analogy to the procedure described in Example 14 but using 8-(2-fluoro-phenyl)-quinoxaline-5-carboxylic acid (Example 44) in Step 14.1. Title compound: ESI-MS: 334.0 [M+H]+; tR=3.39 min (System 1); TLC: Rf=0.54 (DCM/MeOH, 9:1).

Workup

  1. customThe title compound was prepared in analogy to the procedure

Sources & evidence

ORD record
ord-e54965d27ae04479b24778a6e0842f9f
Source dataset
uspto-grants-2014_03
Patent number
US08674099B2

Reaction notes

Loading…