関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | MeOH tetrahydrofuran | HCID 21899815 | — |
| 反応物 | 8-Benzo[b]thiophen-3-yl-quinoxaline-5-carboxylic acid | HCID 66914636 | — |
| 反応物 | HCID 178480844 | HCID 178480844 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | HCID 178480843 | HCID 178480843 | — |
反応手順
The title compound was prepared in analogy to the procedures described in Example 14 but stirring the reaction mixture for 20 h at 65° C., using 1-methyl-4-(2-nitro-1H-imidazol-4-ylmethyl)-piperazine (Step 20.1) instead of 2-nitroimidazole in Step 14.3, Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2, and 8-benzo[b]thiophen-3-yl-quinoxaline-5-carboxylic acid (Example 59) in Step 14.1. Title compound: ESI-MS: 484.0 [M+H]+; tR=3.36 min (System 1); TLC: Rf=0.10 (DCM/MeOH, 9:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08674099B2 |
|---|
| 出典データセット | uspto-grants-2014_03 |
|---|
| ORD ID | ord-e9bbc96e26c143199281bad6624bdfdc |
|---|
| 出典メモ | uspto-grants-2014_03 |
|---|
