4-[2-(Dimethylamino)ethoxy]aniline → 8-(2,6-Dimethyl-phenyl)-quinoxaline-5-carboxylic acid [4-(2-dimethylamino-ethoxy)-phenyl]-amide

HRID 1189785Notes

Reaction equation

HRID 1189785 reaction equation
[CH3:1][N:2]([CH3:13])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][CH:7]=1.[CH3:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[C:16]=1[C:22]1[C:31]2[N:30]=[CH:29][CH:28]=[N:27][C:26]=2[C:25]([C:32](O)=[O:33])=[CH:24][CH:23]=1>>[CH3:1][N:2]([CH3:13])[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:32]([C:25]2[C:26]3[N:27]=[CH:28][CH:29]=[N:30][C:31]=3[C:22]([C:16]3[C:17]([CH3:21])=[CH:18][CH:19]=[CH:20][C:15]=3[CH3:14])=[CH:23][CH:24]=2)=[O:33])=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 64846554-[2-(Dimethylamino)ethoxy]anilineHCID 669145748-(2,6-Dimethyl-phenyl)quinoxaline-5-carboxylic acid

Product 1

HCID 445166068-(2,6-Dimethyl-phenyl)-quinoxaline-5-carboxylic acid [4-(2-dimethylamino-ethoxy)-phenyl]-amide

Procedure

The title compound was prepared in analogy to the procedure described in Step 14.1 but using 4-(2-dimethylamino-ethoxy)-phenylamine (Step 5.1) and 8-(2,6-dimethyl-phenyl)-quinoxaline-5-carboxylic acid (Example 71). Title compound: ESI-MS: 441.1 [M+H]+; tR=3.52 min (System 3).

Workup

  1. customThe title compound was prepared in analogy to the procedure

Sources & evidence

ORD record
ord-bc5e509479c3429a82dce5146a7e1a6c
Source dataset
uspto-grants-2014_03
Patent number
US08674099B2

Reaction notes

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