HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Aminopyridine → 8-(2,6-Dichloro-3,5-dimethoxy-phenyl)-2-[(2-dimethylamino-ethyl)-methylamino]-quinoxaline-5-carboxylic acid pyridin-3-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Aminopyridine | HCID 10009 | — |
| Reactant | 8-(2,6-Dichloro-3,5-dimethoxy-phenyl)-2-[(2-dimethylamino-ethyl)-methyl-amino]-quinoxaline-5-carboxylic acid | HCID 86641142 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 8-(2,6-Dichloro-3,5-dimethoxy-phenyl)-2-[(2-dimethylamino-ethyl)-methylamino]-quinoxaline-5-carboxylic acid pyridin-3-ylamide | HCID 59292906 | — |
Reaction Steps
The title compound was prepared in analogy to the procedure described in Step 14.1 but using 8-(2,6-dichloro-3,5-dimethoxy-phenyl)-2-[(2-dimethylamino-ethyl)-methyl-amino]-quinoxaline-5-carboxylic acid (Step 85.1) and 3-aminopyridine. Title compound: ESI-MS: 555.0/557.2 [M+H]+; tR=3.16 min (System 1); TLC: Rf=0.20 (DCM/MeOH/NH3aq, 94:5:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674099B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-d5cde277414e4e9abf8cc5b306af6d03 |
| Source note | uspto-grants-2014_03 |