HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 178493458, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | MeOH tetrahydrofuran | HCID 21899815 | — |
| Reactant | 8-(2-Chloro-6-fluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester | HCID 86641146 | — |
| Reactant | HCID 178516762 | HCID 178516762 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 178493458 | HCID 178493458 | — |
Reaction Steps
The title compound was prepared in analogy to the procedures described in Example 14 but using 8-(2-chloro-6-fluoro-3,5-dimethoxy-phenyl)-quinoxaline-5-carboxylic acid ethyl ester (Step 144.1), Raney nickel and MeOH/THF (1:1) instead of palladium on carbon and MeOH in Step 14.2, and 4-(2-nitro-1H-imidazol-4-ylmethyl)-piperazin-2-one (Step 142.1) instead of 2-nitroimidazole in Step 14.3. Title compound: ESI-MS: 540.0 [M+H]+; tR=3.18 min (System 1); TLC: Rf=0.18 (DCM/MeOH, 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674099B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-da467c6db8594cd0a0a60d272ac070ff |
| Source note | uspto-grants-2014_03 |