Boc-Pro-D-Pro-OBn → Boc-Pro-D-Pro-OH

Participants

Reaction Steps

2.05 g of Pd/C (ASCA-2, ca. Pd 5 wt %, 50% wet) was added to 41 ml of methanol solution of 4.10 g (10.2 mmol) of Boc-Pro-D-Pro-OBn obtained in Synthesis Example 1-1, followed by stirring for 20 hours at room temperature under a hydrogen atmosphere. After a reaction mixture was filtrated by celite, the filtrate was concentrated under reduced pressure, thereby obtaining the product with a yield of 100%.

Provenance & Evidence