Cyclohexanecarboxaldehyde → HCID 67296430, compound

HRID 1189970Notes

Reaction equation

HRID 1189970 reaction equation
[OH:1][CH:2]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-])=O)[CH:8]=1)[CH:3]([CH3:6])[C:4]#[N:5].[CH:16]1([CH:22]=O)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[CH:16]1([CH2:22][NH:13][C:9]2[CH:8]=[C:7]([CH:2]([OH:1])[CH:3]([CH3:6])[C:4]#[N:5])[CH:12]=[CH:11][CH:10]=2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 16275CyclohexanecarboxaldehydeHCID 67296555HCID 67296555, compound

Product 1

HCID 67296430HCID 67296430, compound

Procedure

Hydrogenation of the mixture of 3-hydroxy-2-methyl-3-(3-nitrophenyl)propanenitrile and aldehyde 29 following the method used in Example 11 gives 3-(3-(cyclohexylmethylamino)phenyl)-3-hydroxy-2-methylpropanenitrile.

Sources & evidence

ORD record
ord-e835d72a6aa64e6cbd683d205e563cfb
Source dataset
uspto-grants-2014_03
Patent number
US08674137B2

Reaction notes

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