HCID 86641456, compound → HCID 68524524, compound

Participants

Reaction Steps

A mixture of tert-butyl (3-(3-(cyclohexylmethylamino)phenyl)oxiran-2-yl)methylcarbamate, HCOOH.Et3N complex (5:2), Pd/C (10% wt) in absolute EtOH is degassed by applying vacuum/argon 3 times. The reaction mixture is stirred at room temperature until no starting material is seen by TLC, then concentrated under reduced pressure. Purification by flash chromatography (EtOAc—hexanes gradient) gives tert-butyl 3-(3-(cyclohexylmethylamino)phenyl)-2-hydroxypropylcarbamate.

Provenance & Evidence