2-Cyclohexylethanesulfonyl chloride → Tert-butyl 3-(3-(2-cyclohexylethylsulfonamido)phenyl)propylcarbamate

HRID 1189976Notes

Reaction equation

HRID 1189976 reaction equation
C1(C[NH:8][C:9]2[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])[CH:12]=[CH:13][CH:14]=2)CCCCC1.[CH:26]1([CH2:32][CH2:33][S:34](Cl)(=[O:36])=[O:35])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1>>[CH:26]1([CH2:32][CH2:33][S:34]([NH:8][C:9]2[CH:10]=[C:11]([CH2:15][CH2:16][CH2:17][NH:18][C:19](=[O:25])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH:12]=[CH:13][CH:14]=2)(=[O:36])=[O:35])[CH2:31][CH2:30][CH2:29][CH2:28][CH2:27]1

Participants

3

Reactant 2

HCID 225004012-Cyclohexylethanesulfonyl chlorideHCID 59317002Tert-butyl 3-(3-(cyclohexylmethylamino)phenyl)propylcarbamate

Product 1

HCID 68525298Tert-butyl 3-(3-(2-cyclohexylethylsulfonamido)phenyl)propylcarbamate

Procedure

Sulfonation of aniline 17 by 2-cyclohexylethanesulfonyl chloride following the method used in Example 6 gives tert-butyl 3-(3-(2-cyclohexylethylsulfonamido)phenyl)propylcarbamate.

Sources & evidence

ORD record
ord-4bd5291e7add4f0594f6846da741d48e
Source dataset
uspto-grants-2014_03
Patent number
US08674137B2

Reaction notes

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