HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 119Generated: October 28, 2026
1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester → 4-N-[1-(3,5-difluoro-2-pyridinyl)ethyl]-5-fluoro-2-N-(5-methyl-1H-pyrazol-3-yl)-6-morpholin-4-ylpyrimidine-2,4-diamine
https://huagongshe.com/reaction/119
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1H-Pyrazole-1-carboxylicacid,3-amino-5-methyl-,1,1-dimethylethylester | HCID 11321537 | — |
| Reactant | HCID 78133295 | HCID 78133295 | — |
| Reagent | Cesium carbonate | HCID 10796 | — |
| Catalyst | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| Catalyst | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-N-[1-(3,5-difluoro-2-pyridinyl)ethyl]-5-fluoro-2-N-(5-methyl-1H-pyrazol-3-yl)-6-morpholin-4-ylpyrimidine-2,4-diamine | HCID 25103038 | 0% |
Reaction Steps
9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene (27.9 mg, 0.05 mmol), 2-chloro-N-(1-(3,5-difluoropyridin-2-yl)ethyl)-5-fluoro-6-morpholinopyrimidin-4-amine (200 mg, 0.54 mmol), tert-butyl 3-amino-5-methyl-1H-pyrazole-1-carboxylate (127 mg, 0.64 mmol) and cesium carbonate (349 mg, 1.07 mmol) were added to dioxane (8 mL). The mixture was purged with nitrogen for 15 minutes. Pd2(dba)3 (29.4 mg, 0.03 mmol) was added and the mixture heated at 110 °C for 3h. No sign of any reaction.
Provenance & Evidence
| Source dataset | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-20af979b60da4f278f5b92ae2abaf8ca |
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| Source note | 750 AstraZeneca ELN dataset |
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