3-(Bromomethyl)pyridine → HCID 178461269, compound

HRID 1190037Notes

Reaction equation

HRID 1190037 reaction equation
C[O:2][C:3]([C:5]1[S:6][C:7]([C:26]2[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]=2)=[CH:8][C:9]=1[N:10]([C:17]([C@H:19]1[CH2:24][CH2:23][C@H:22]([CH3:25])[CH2:21][CH2:20]1)=[O:18])[CH:11]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]1)=[O:4].Br[CH2:33][C:34]1[CH:35]=[N:36][CH:37]=[CH:38][CH:39]=1>>[C:26]1([C:7]2[S:6][C:5]([C:3]([OH:2])=[O:4])=[C:9]([N:10]([C:17]([C@H:19]3[CH2:24][CH2:23][C@H:22]([CH3:25])[CH2:21][CH2:20]3)=[O:18])[CH:11]3[CH2:12][CH2:13][N:14]([CH2:33][C:34]4[CH:35]=[N:36][CH:37]=[CH:38][CH:39]=4)[CH2:15][CH2:16]3)[CH:8]=2)[CH2:31][CH2:30][CH2:29][CH2:28][CH:27]=1

Participants

3

Reactant 2

HCID 2459343-(Bromomethyl)pyridineHCID 178499271HCID 178499271, compound

Product 1

HCID 178461269HCID 178461269, compound

Procedure

Alkylation of 5-cyclohex-1-enyl-3-[(trans-4-methyl-cyclohexanecarbonyl)-piperidin-4-yl-amino]-thiophene-2-carboxylic acid methyl ester with 3-bromomethylpyridine and subsequent hydrolysis of the derived ester afforded the title compound compound #121

Sources & evidence

ORD record
ord-f8a9dfaff92346ba8459d5c5046ab92e
Source dataset
uspto-grants-2014_03
Patent number
US08674118B2

Reaction notes

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