Formaldehyde → Methyl thenoate

HRID 1190052Notes

Reaction equation

[CH3:1][O:2][C:3]([C:5]1[S:6][C:7](C2CCC(C)(C)CC2)=[CH:8][C:9]=1N(C(CO)CO)C([C@H]1CC[C@H](C)CC1)=O)=[O:4].C=O>>[CH3:1][O:2][C:3]([C:5]1[S:6][CH:7]=[CH:8][CH:9]=1)=[O:4]

Participants

Reactant 2

HCID 712Formaldehyde

HCID 178499291HCID 178499291, compound

Product 1

HCID 79340Methyl thenoate

Procedure

5-(4,4-Dimethyl-cyclohexyl)-3-[1,3]dioxan-5-yl-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid methyl ester was prepared from 5-(4,4-dimethyl-cyclohexyl)-3-[(2-hydroxy-1-hydroxymethyl-ethyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid methyl ester using paraformaldehyde following a procedure described earlier (example 38, step IV).

Sources & evidence

ORD record: ord-400b94503fff4f23b35fad3dcd14930e
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08674118B2

Reaction notes

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