HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 59457531, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4,4-Dimethylcyclohexen-1-ylboronic acid | HCID 44119555 | — |
| Reactant | 6-Bromo-2-iodopyridin-3-amine | HCID 53401177 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | HCID 59457531 | HCID 59457531 | — |
Reaction Steps
The title compound was prepared from 6-bromo-2-iodo-pyridin-3-ylamine (as prepared in the previous step, 348 mg, 1.17 mmol), 4,4-dimethylcyclohexen-1-yl boronic acid (198 mg, 1.28 mmol), Pd(PPh3)4 (135 mg, 0.117 mol) and 2M Na2CO3 (15.2 mL, 30.5 mmol) according to the procedure in Example 34, step (b) (417 mg, 46%). 1H-NMR (CDCl3; 400 MHz): δ 7.06 (d, 1H, J=8.3 Hz), 6.85 (d, 1H, J=8.3 Hz), 5.95 (m, 1H), 3.86 (br s, 2H), 2.43-2.39 (m, 2H), 1.99-1.97 (m, 2H), 1.51 (t, 2H, J=6.4 Hz), 0.99 (s, 6H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08674100B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-df7f4b291fc3439b972557923429294b |
| Source note | uspto-grants-2014_03 |