4,4-Dimethylcyclohexen-1-ylboronic acid → HCID 58994393, compound

HRID 1190199Notes

Reaction equation

HRID 1190199 reaction equation
Br[C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[CH:4][C:3]=1[NH2:16].[CH3:17][C:18]1([CH3:27])[CH2:23][CH2:22][C:21](B(O)O)=[CH:20][CH2:19]1>>[CH3:17][C:18]1([CH3:27])[CH2:23][CH2:22][C:21]([C:2]2[CH:7]=[C:6]([CH2:8][CH2:9][N:10]3[CH2:15][CH2:14][O:13][CH2:12][CH2:11]3)[CH:5]=[CH:4][C:3]=2[NH2:16])=[CH:20][CH2:19]1

Participants

3

Reactant 2

HCID 441195554,4-Dimethylcyclohexen-1-ylboronic acidHCID 589944272-Bromo-4-(2-morpholin-4-yl-ethyl)-phenylamine

Product 1

HCID 58994393HCID 58994393, compound

Procedure

The title compound was prepared by Suzuki coupling of 2-bromo-4-(2-morpholin-4-yl-ethyl)-phenylamine (as prepared in Example 33, step (b)) and 4,4-dimethyl-1-cyclohexen-1-ylboronic acid according to the procedure in Example 1, step (e). Mass spectrum (ESI, m/z): Calcd. for C20H30N2O, 315.2 (M+H). found 315.1.

Sources & evidence

ORD record
ord-9e8de4910d6e45c0b4a2b6191b20def6
Source dataset
uspto-grants-2014_03
Patent number
US08674100B2

Reaction notes

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