1-Piperazinylpyrazine → HCID 58203946, compound

HRID 1190388Notes

Reaction equation

HRID 1190388 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18](O)=[O:19])[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[N:23]1([C:29]2[CH:34]=[N:33][CH:32]=[CH:31][N:30]=2)[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[NH:2]1[CH:3]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18]([N:26]5[CH2:27][CH2:28][N:23]([C:29]6[CH:34]=[N:33][CH:32]=[CH:31][N:30]=6)[CH2:24][CH2:25]5)=[O:19])[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:5]=[N:1]1

Participants

3

Reactant 2

HCID 27346391-PiperazinylpyrazineHCID 582038838-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

Product 1

HCID 58203946HCID 58203946, compound

Procedure

Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with 2-(piperazin-1-yl)pyrazine (1.2 equiv) to give 178 (8.7 mg, M+1 460.1)

Sources & evidence

ORD record
ord-104d066da82e43ca9808af930db6c055
Source dataset
uspto-grants-2014_03
Patent number
US08673952B2

Reaction notes

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