1-(6-Methylpyridin-2-yl)piperazine → HCID 58203782, compound

HRID 1190407Notes

Reaction equation

HRID 1190407 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18]([OH:20])=O)[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[CH3:23][C:24]1[N:29]=[C:28]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH:27]=[CH:26][CH:25]=1>>[CH3:23][C:24]1[N:29]=[C:28]([N:30]2[CH2:35][CH2:34][N:33]([C:18]([C:12]3[S:13][C:14]4[CH2:15][CH2:16][O:17][C:8]5[CH:7]=[C:6]([C:4]6[CH:3]=[N:2][NH:1][CH:5]=6)[CH:22]=[CH:21][C:9]=5[C:10]=4[N:11]=3)=[O:20])[CH2:32][CH2:31]2)[CH:27]=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 27369461-(6-Methylpyridin-2-yl)piperazineHCID 582038838-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

Product 1

HCID 58203782HCID 58203782, compound

Procedure

Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with 1-(6-methylpyridin-2-yl)piperazine (1.2 equiv) to give 198 (M+1 473.0)

Sources & evidence

ORD record
ord-6f603e7d105a42fd9fe5744eaf4d2173
Source dataset
uspto-grants-2014_03
Patent number
US08673952B2

Reaction notes

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