(4-Methylpiperazin-1-yl)(piperidin-4-yl)methanone → HCID 58204159, compound

HRID 1190413Notes

Reaction equation

HRID 1190413 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18](O)=[O:19])[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[CH3:23][N:24]1[CH2:29][CH2:28][N:27]([C:30]([CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)=[O:31])[CH2:26][CH2:25]1>>[CH3:23][N:24]1[CH2:25][CH2:26][N:27]([C:30]([CH:32]2[CH2:37][CH2:36][N:35]([C:18]([C:12]3[S:13][C:14]4[CH2:15][CH2:16][O:17][C:8]5[CH:7]=[C:6]([C:4]6[CH:5]=[N:1][NH:2][CH:3]=6)[CH:22]=[CH:21][C:9]=5[C:10]=4[N:11]=3)=[O:19])[CH2:34][CH2:33]2)=[O:31])[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 2760037(4-Methylpiperazin-1-yl)(piperidin-4-yl)methanoneHCID 582038838-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

Product 1

HCID 58204159HCID 58204159, compound

Procedure

Following the procedure for 103, 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid (50.0 mg, 0.2 mmol) was reacted with (4-methylpiperazin-1-yl)(piperidin-4-yl)methanone (1.2 equiv) to give 205 (M+1 507.0)

Sources & evidence

ORD record
ord-4c3a145884ec4a4e9ec2baf69fc0b41a
Source dataset
uspto-grants-2014_03
Patent number
US08673952B2

Reaction notes

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