4-(3R)-3-Pyrrolidinyl-morpholine → HCID 67061757, compound

HRID 1190430Notes

Reaction equation

HRID 1190430 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]2[CH:22]=[CH:21][C:9]3[C:10]4[N:11]=[C:12]([C:18](O)=[O:19])[S:13][C:14]=4[CH2:15][CH2:16][O:17][C:8]=3[CH:7]=2)[CH:3]=[N:2]1.[NH:23]1[CH2:27][CH2:26][C@@H:25]([N:28]2[CH2:33][CH2:32][O:31][CH2:30][CH2:29]2)[CH2:24]1>>[N:28]1([C@@H:25]2[CH2:26][CH2:27][N:23]([C:18]([C:12]3[S:13][C:14]4[CH2:15][CH2:16][O:17][C:8]5[CH:7]=[C:6]([C:4]6[CH:3]=[N:2][NH:1][CH:5]=6)[CH:22]=[CH:21][C:9]=5[C:10]=4[N:11]=3)=[O:19])[CH2:24]2)[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1

Participants

3

Reactant 2

HCID 71762784-(3R)-3-Pyrrolidinyl-morpholineHCID 582038838-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid

Product 1

HCID 67061757HCID 67061757, compound

Procedure

Following Example 216, to a well stirred solution of 8-(1H-Pyrazol-4-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene-2-carboxylic acid and (R)-4-(pyrrolidin-3-yl)morpholine to give 228. MS: (ESI+)=453.1

Sources & evidence

ORD record
ord-502822dfcb9140e5973f7c816052202a
Source dataset
uspto-grants-2014_03
Patent number
US08673952B2

Reaction notes

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