1-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol ester → 2-{4-[2-(2-Pyridin-4-ylmethyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-8-yl]-pyrazol-1-yl}-ethanol

HRID 1190502Notes

Reaction equation

HRID 1190502 reaction equation
Br[C:2]1[CH:27]=[CH:26][C:5]2[C:6]3[N:7]=[C:8]([C:14]4[N:15]([CH2:19][C:20]5[CH:25]=[CH:24][N:23]=[CH:22][CH:21]=5)[N:16]=[CH:17][N:18]=4)[S:9][C:10]=3[CH2:11][CH2:12][O:13][C:4]=2[CH:3]=1.CC1(C)C(C)(C)OB([C:36]2[CH:37]=[N:38][N:39]([CH2:41][C:42](OCC)=[O:43])[CH:40]=2)O1.[H-].[Al+3].[Li+].[H-].[H-].[H-].C(N1C(C2SC3CCOC4C=C(C5C=NN(CCO)C=5)C=CC=4C=3N=2)=NC=N1)(C)C>>[N:23]1[CH:22]=[CH:21][C:20]([CH2:19][N:15]2[C:14]([C:8]3[S:9][C:10]4[CH2:11][CH2:12][O:13][C:4]5[CH:3]=[C:2]([C:36]6[CH:37]=[N:38][N:39]([CH2:41][CH2:42][OH:43])[CH:40]=6)[CH:27]=[CH:26][C:5]=5[C:6]=4[N:7]=3)=[N:18][CH:17]=[N:16]2)=[CH:25][CH:24]=1

Participants

5

Reactant 4

HCID 162183851-(Ethoxycarbonylmethyl)-1H-pyrazole-4-boronic acid pinacol esterHCID 21226445Aluminium lithium hydrideHCID 568325102-{4-[2-(2-Isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-8-yl]pyrazol-1-yl}-ethanolHCID 582042368-Bromo-2-(2-pyridin-4-ylmethyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene

Product 1

HCID 582041882-{4-[2-(2-Pyridin-4-ylmethyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-8-yl]-pyrazol-1-yl}-ethanol

Procedure

Similarly to as described in General Procedure C: 8-Bromo-2-(2-pyridin-4-ylmethyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulene was reacted with ethyl 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetate. The crude ester was reduced with lithium aluminum hydride as described for 2-{4-[2-(2-Isopropyl-2H-[1,2,4]triazol-3-yl)-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-8-yl]-pyrazol-1-yl}-ethanol. The product was purified by HPLC to give 302 as a colorless solid (32 mg). LCMS: 472.1.

Workup

  1. customThe product was purified by HPLC

Sources & evidence

ORD record
ord-9a31883682f347f1b345c08b387e6433
Source dataset
uspto-grants-2014_03
Patent number
US08673952B2

Reaction notes

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