HCID 67050627, compound → HCID 58203884, compound

HRID 1190657Notes

Reaction equation

HRID 1190657 reaction equation
Br[C:2]1[CH:24]=[CH:23][C:5]2[C:6]3[N:7]=[C:8]([C:14]4[N:15]([CH:20]([CH3:22])[CH3:21])[C:16](=[O:19])[NH:17][N:18]=4)[S:9][C:10]=3[CH2:11][CH2:12][O:13][C:4]=2[CH:3]=1.[CH3:25][C:26]1([CH2:30][N:31]2[CH:35]=[C:34](B3OC(C)(C)C(C)(C)O3)[CH:33]=[N:32]2)[CH2:29][O:28][CH2:27]1>>[CH:20]([N:15]1[C:14]([C:8]2[S:9][C:10]3[CH2:11][CH2:12][O:13][C:4]4[CH:3]=[C:2]([C:34]5[CH:33]=[N:32][N:31]([CH2:30][C:26]6([CH3:25])[CH2:27][O:28][CH2:29]6)[CH:35]=5)[CH:24]=[CH:23][C:5]=4[C:6]=3[N:7]=2)=[N:18][NH:17][C:16]1=[O:19])([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 67050627HCID 67050627, compoundHCID 67050704HCID 67050704, compound

Product 1

HCID 58203884HCID 58203884, compound

Procedure

Similarly to as described in General Procedure C, 5-(8-Bromo-4,5-dihydro-6-oxa-3-thia-1-aza-benzo[e]azulen-2-yl)-4-isopropyl-2,4-dihydro-[1,2,4]triazol-3-one was reacted with 1-((3-methyloxetan-3-yl)methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Purification of the crude reaction mixture by reverse phase HPLC gave 456. LCMS: 479.1

Workup

  1. customPurification of the crude
  2. customreaction mixture by reverse phase HPLC

Sources & evidence

ORD record
ord-39c63b9589cb45fa98d5cf1c7ad8575c
Source dataset
uspto-grants-2014_03
Patent number
US08673952B2

Reaction notes

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