Telaprevir → HCID 178508939, compound

HRID 1190765Notes

Reaction equation

O.[NH2:2][C:3]1[NH:4][C:5](=[O:22])[C:6]2[S:11][C:10](=[O:12])[N:9]([C@@H:13]3[O:19][C@H:18]([CH2:20][OH:21])[C@@H:16]([OH:17])[C@H:14]3[OH:15])[C:7]=2[N:8]=1.S1C2C(=O)N=CNC=2NC1=O.CCC[C@H](NC([C@H]1N(C([C@@H](NC([C@@H](NC(C2C=NC=CN=2)=O)C2CCCCC2)=O)C(C)(C)C)=O)C[C@H]2[C@@H]1CCC2)=O)C(C(NC1CC1)=O)=O>>[CH2:20]([OH:21])[C@H:18]1[O:19][C@@H:13]([N:9]2[C:10](=[O:12])[S:11][C:6]3[C:5]([N:4]=[C:3]([NH2:2])[NH:8][C:7]2=3)=[O:22])[C@H:14]([OH:15])[C@@H:16]1[OH:17]

Participants

Reactant 3

HCID 3010818Telaprevir

HCID 135484549Isatoribine

HCID 178518672HCID 178518672, compound

Product 1

HCID 178508939HCID 178508939, compound

Procedure

5-Amino-3-beta-D-ribofuranosylthiazolo(4,5-d)pyrimidine-2,7(3H,6H)-dione monohydrate; Thiazolo(4,5-d)pyrimidine-2,7(3H,4H)-dione, 5-amino-3-beta-D-ribofuranosyl-, monohydrate); VX-950

Sources & evidence

ORD record: ord-e68aa3d0c4e74845aff8feb53cc5a900
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08679472B1

Reaction notes

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