Isopropanol → HCID 14178475, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of L-Leucine (1 g, 1 eq.), SOCl2 (1.7 ml, 3 eq.) in isopropanol (15 ml) was stirred under microwave irradiation at 100° C. for 1 hour. Solvent was then evaporated, the residue filtered and Et2O was added to give L-Leucine isopropyl ester as a yellow oil in 71% yield. 1H NMR (DMSO-d6, 400 MHz) δ (ppm): 0.88 (dd, J=6.41 Hz and J=2.14 Hz, 6H), 1.22 (t, J=6.03 Hz, 6H), 1.60-1.75 (m, 3 H), 3.82 (t, J=7.10 Hz, 1H), 4.97 (m, 1H), 8.61 (s, 2H).

Provenance & Evidence