4-(Bromomethyl)benzonitrile → HCID 70975625, compound

Participants

Reaction Steps

The specific operation referred to the step (5) described in Example 1 for details. 347 mg (R)-1-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)piperidin-3-yl carbamic acid ter.-butyl ester (1 mmol) and 235 mg 4-(bromomethyl)benzonitrile (1.2 mmol) were charged. A column chromatography was performed to afford 350 mg titled product with a yield of 75.6%.

Provenance & Evidence