HCID 70975558, compound → HCID 53312240, compound

Participants

Reaction Steps

1.24 g (R)-1-[1-(2-cyanobenzyl)-3-(2,4-dimethoxybenzyl)-5-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl]piperidine-3-carbamic acid tert-butyl ester (2.02 mmol) was dissolved in 8 mL anisole, to which 1.5 mL trifluoroacetic acid was added, and reacted for 24 h at 90° C. The reaction solution was evaporated to dryness. The residue was dissolved in a small amount of water, and washed with ethyl acetate. The aqueous phase was adjusted to basic with saturated sodium carbonate solution, and extracted with dichloromethane for five times. The dichloromethane phase was combined, dried and evaporated to dryness to afford 0.4 g titled product with a yield of 54.5%.

Provenance & Evidence