HCID 70975660, compound → HCID 70975608, compound

HRID 1190823Notes

Reaction equation

HRID 1190823 reaction equation
[C:1]([O:5][C:6](=[O:29])[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][N:10]([C:14]2[C:19]([N+:20]([O-])=O)=[C:18]([NH:23][CH3:24])[N:17]=[C:16]([C:25]([O:27][CH3:28])=[O:26])[CH:15]=2)[CH2:9]1)([CH3:4])([CH3:3])[CH3:2].[H][H]>C(O)C.[Pd]>[C:1]([O:5][C:6](=[O:29])[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][N:10]([C:14]2[C:19]([NH2:20])=[C:18]([NH:23][CH3:24])[N:17]=[C:16]([C:25]([O:27][CH3:28])=[O:26])[CH:15]=2)[CH2:9]1)([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 2

HCID 70975660HCID 70975660, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 70975608HCID 70975608, compoundYield 92.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

In a dry reaction bottle, 6.54 g (R)-1-[2-methoxycarbonyl-5-nitro-6-methylaminopyridin-4-yl]piperidine-3-carbamic acid tert-butyl ester (16 mmol) was added and dissolved in 200 mL ethanol. 0.65 g 10% Pd—C was added at room temperature. The stirring was continued for 4 h by introducing hydrogen gas. The reaction solution was filtrated, and evaporated to dryness to afford 5.6 g light yellow solid with a yield of 92.3%.

Workup

  1. additionwas added
  2. filtrationThe reaction solution was filtrated
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-1d138b2b93994ce9bc1305cf2f557567
Source dataset
uspto-grants-2014_03
Patent number
US08680089B2

Reaction notes

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