反应详情

In a dry reaction bottle, 6.54 g (R)-1-[2-methoxycarbonyl-5-nitro-6-methylaminopyridin-4-yl]piperidine-3-carbamic acid tert-butyl ester (16 mmol) was added and dissolved in 200 mL ethanol. 0.65 g 10% Pd—C was added at room temperature. The stirring was continued for 4 h by introducing hydrogen gas. The reaction solution was filtrated, and evaporated to dryness to afford 5.6 g light yellow solid with a yield of 92.3%.

1. additionwas added
2. filtrationThe reaction solution was filtrated
3. customevaporated to dryness