Potassium borohydride → HCID 70975437, compound

Participants

Reaction Steps

1.04 g (R)-7-(3-tert-butoxycarbonylaminopiperidin-1-yl)-1-(2-cyanobenzyl)-3-methyl-5-methoxycarbonyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine (2 mmol) was dissolved in 20 mL ethanol, to which 0.42 g potassium borohydride (8 mmol) was added in an ice bath. The stirring was continued at room temperature overnight. The reaction was monitored by TLC. After the reaction was finished, it was quenched by adding water. The reaction solution was extracted with dichloromethane for three times. The organic phase was combined, washed with saturated brine, dried with anhydrous sodium sulfate, and evaporated to dryness to afford 0.84 g crude product with a yield of 85.4%.

Provenance & Evidence