Potassium Carbonate → HCID 68304833, compound

Participants

Reaction Steps

15.1 g (R)-2-[[7-(3-aminopiperidin-1-yl)-3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile (40.1 mmol) was added in a reaction bottle, to which 30 mL DMF was added. 8.6 g 2-cyano-benzyl bromide (44 mmol) and 11 g potassium carbonate (80 mmol) were added at 0° C. The reaction was continued for 3 h by stirring at room temperature. The reaction solution was extracted with dichloromethane, and washed with saturated sodium chloride solution. The organic layer was dried with anhydrous sodium sulfate, and evaporated to dryness to afford 19.68 g crude product with a yield of 99.8%.

Provenance & Evidence