(3S)-4-(benzyloxy)-3-(((tert-butoxy)carbonyl)amino)-4-oxobutanoic acid → HCID 86707731, compound

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Compound 45a was prepared from (S)-4-(benzyloxy)-3-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid and 2-(6-phenylbenzo[d]thiazol-2-yl)acetohydrazide (described in WO 2011/074560) in 42% yield as a yellow solid using the general procedure given for Compound 1b. LCMS=1.13 min using analytical method (M), 571.2 (M+H). 1H NMR (400 MHz, CDCl3) δ 8.19-7.95 (m, 2H), 7.79-7.55 (m, 3H), 7.47 (t, J=7.7 Hz, 2H), 7.42-7.27 (m, 6H), 5.56 (d, J=7.0 Hz, 1H), 5.14 (s, 2H), 4.79 (br. s., 1H), 4.65 (s, 2H), 3.52-3.23 (m, 2H), 1.49-1.32 (m, 9H).

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