(5-Methyl-2,4-dioxo-1,3-thiazolidin-5-yl)acetic acid → tert-Butyl 2-((5-((2,4-dioxothiazolidin-5-yl)methyl)-1,3,4-oxadiazol-2-yl)methyl)benzo[d]thiazole-6-carboxylate

Participants

Reaction Steps

Compound 188d was prepared from Compound 188c in 38% yield as a white solid using the general procedure given for Compound 1a. LCMS=1.88 min using analytical method (B), 447.0 (M+H). 1H NMR (400 MHz, CDCl3) δ 8.54 (d, J=1.1 Hz, 1H), 8.14 (dd, J=8.6, 1.5 Hz, 1H), 8.04 (d, J=8.6 Hz, 1H), 4.82 (dd, J=9.2, 4.2 Hz, 1H), 4.76 (s, 2H), 3.82-3.76 (m, 1H), 3.49 (m, 1H), 1.64 (s, 9H).

Provenance & Evidence