4,7-Dichloroquinoline → {5-[(7-Chloroquinolin-4-yl)amino]-2-(4-methylpiperazin-1-yl)phenyl}methanol

Participants

Reaction Steps

[5-amino-2-(4-methylpiperazin-1-yl)phenyl]methanol (100 mg, 0.45 mmol) and 4,7-dichloroquinoline (94 mg, 1.1 eq) were refluxed in 1 mL of n-pentanol overnight. The reaction mixture was then evaporated and purified by flash chromatography (DCM/MeOH/NH4OH//8/2/0.1) to yield expected compound as a pale brown solid (143 mg, 83% yield). m/z (ESI) 383.1 [M+H]+;

Provenance & Evidence