Cesium carbonate → HCID 53328344, compound

Participants

Reaction Conditions

Reaction Steps

In a oven-dried flask and under a nitrogen atmosphere, were placed tert-butyl N-[(2-bromo-3-methyl-5-nitrophenyl)methyl]carbamate (150 mg, 0.43 mmol), (+/−) BINAP (14 mg, 0.05 eq), Cs2CO3 (196 mg, 1.4 eq), Pd2dba3 (10 mg, 0.05 eq) and 3 mL of dry 1,4-dioxanne. N-Methylpiperazine (58 μL, 1.2 eq) was added and the mixture was stirred at 90° C. for 16 h. The solution was filtered through a celite pad and evaporated. The residue was purified by flash chromatography on silica gel (DCM/MeOH/NEt3//9/1/0.1) to yield expected compound as a pale brown solid (100 mg, 64% yield). m/z (ESI) 365.2 [M+H]+;

Provenance & Evidence