Acetyl chloride → HCID 53328346, compound

Participants

Reaction Steps

1.2 mL of acetyl chloride was slowly added to 10 mL of MeOH at 0° C. The solution was stirred for 30 min at room temperature and then tert-butyl N-{[3-methyl-2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methyl}carbamate (300 mg, 0.82 mmol) dissolved in 5 mL of MeOH was added. The reaction mixture was stirred for 2 h and then evaporated. The residue was dissolved in 15 mL of water and washed with diethyl ether. The aqueous layer was made alkaline (pH=10) with an aqueous NaOH 1M and extracted with DCM. The combined organic layers were dried over Na2SO4, filtered and evaporated to yield expected compound as a pale yellow oil (216 mg, quantitative yield). m/z (ESI) 265.2 [M+H]+;

Provenance & Evidence