Ammonium formate → HCID 53328351, compound

Participants

Reaction Steps

1-Methyl-4-[2-methyl-4-nitro-6-(pyrrolidin-1-ylmethyl)phenyl]piperazine (90 mg, 0.28 mmol) was hydrogenated using ammonium formate (107 mg, 6 eq) and Pd/C (10% Pd, 15 mg, 0.05 eq) in 2 mL of EtOH. The mixture was stirred overnight at room temperature and then filtered through a celite pad. The filtrate was evaporated and the residue was dissolved in DCM and washed with a saturated aqueous solution of Na2CO3. The aqueous layer was extracted with DCM. The combined organic layers were dried over Na2SO4, filtered and evaporated to yield expected compound as a pale yellow oil (84 mg, quantitative yield).

Provenance & Evidence