Hydrochloric Acid → HCID 53328146, compound

Participants

Reaction Steps

3-Methyl-4-(4-methylpiperazin-1-yl)-5-(pyrrolidin-1-ylmethyl)aniline (70 mg, 0.24 mmol) and 4,7-dichloroquinoline (50 mg, 1 eq) were refluxed overnight in 5 mL of acetonitrile with 1.25 mL of HCl 1M. The reaction mixture was then evaporated and purified by flash chromatography (DCM/MeOH/NH4OH//9/1/0.1) to yield expected compound as a white solid (92 mg, 84% yield). m/z (ESI) 450.1 [M+H]+;

Provenance & Evidence