Ammonium formate → HCID 67247561, compound

Participants

Reaction Steps

4-{[3-Methyl-2-(4-methylpiperazin-1-yl)-5-nitrophenyl]methyl}morpholine-piperazine (113 mg, 0.34 mmol) was hydrogenated using ammonium formate (213 mg, 10 eq) and Pd/C (10% Pd, 36 mg, 0.05 eq) in 5 mL of EtOH. The mixture was stirred overnight at room temperature and then filtered through a celite pad. The filtrate was evaporated and the residue was dissolved in DCM and washed with a saturated aqueous solution of Na2CO3. The aqueous layer was extracted with DCM. The combined organic layers were dried over Na2SO4, filtered and evaporated to yield expected compound as a pale yellow oil (92 mg, 89% yield).

Provenance & Evidence