Ammonium formate → HCID 53328723, compound

Participants

Reaction Steps

4-[2-Methyl-4-nitro-6-(pyrrolidin-1-ylmethyl)phenyl]morpholine (62 mg, 0.20 mmol) was hydrogenated using ammonium formate (128 mg, 2.00 mmol) and Pd/C (10% Pd, 21 mg, 0.02 mmol) in 2 mL of EtOH. The mixture was stirred overnight at room temperature and then filtered through a celite pad. The filtrate was evaporated and the residue was dissolved in DCM and washed with a saturated aqueous solution of Na2CO3. The aqueous layer was extracted with DCM. The combined organic layers were dried over Na2SO4, filtered and evaporated to yield expected compound as a pale yellow oil (55 mg, 99% yield); m/z (ESI) 276.3 [M+H]+.

Provenance & Evidence