Ethyl Acetate → HCID 70944847, compound

Participants

Reaction Steps

To a suspension of N-{3,5-bis[(pyrrolidin-1-yl)carbonyl]phenyl}-7-chloroquinolin-4-amine (84 mg, 0.19 mmol) in 15 mL of anhydrous THF, was added portionwise LiAlH4 (71 mg, 10 eq). The reaction mixture was stirred at room temperature for 2 h and then 10 mL of ethyl acetate was added. The mixture was filtered through a celite pad. The filtrate was evaporated and the residue was purified by preparative thin-layer chromatography (DCM/MeOH/NH4OH//95/5/1) to yield expected compound (4 mg, 5%) as a yellow oil. m/z (ESI) 420.9 [M+H]+.

Provenance & Evidence