4-Aminophenol → 4-[(7-chloroquinolin-4-yl)amino]phenol

Participants

Reaction Steps

4-Aminophenol (1.09 g, 10 mmol) and 4,7-dichloroquinoline (1.98 g, 1 eq) were refluxed in 50 mL of ethanol for 2 h. The reaction mixture was then cooled to room temperature and the precipitate was removed by filtration and washed successively with a saturated aqueous solution of NaHCO3, water, methanol and then petroleum ether to yield expected compound as a yellow powder (2.57 g, 95% yield). m/z (ESI) 271.1 [M+H]+.

Provenance & Evidence