4,7-Dichloroquinoline → HCID 70944812, compound

Participants

Reaction Conditions

Reaction Steps

In a oven-dried flask and under a nitrogen atmosphere, were placed 3,5-bis(morpholin-4-yl)aniline (63 mg, 0.22 mmol), 4,7-dichloroquinoline (43 mg, 1 eq), (+/−) BINAP (7 mg, 0.1 eq), Cs2CO3 (99 mg, 1.4 eq), Pd2dba3 (5 mg, 0.02 eq) and 2 mL of dry 1,4-dioxane. The mixture was stirred at 90° C. for 24 h. The solution was filtered through a celite pad and evaporated. The residue was purified by preparative thin-layer chromatography (DCM/MeOH//95/5) to yield expected compound as a yellow solid (27 mg, 29% yield). m/z (ESI) 425.3 [M+H]+;

Provenance & Evidence