Potassium Carbonate → 4-[(3-Amino-5-cyanophenyl)amino]-7-chloro-1-[2-(piperidin-1-yl)ethyl]quinolin-1-ium chloride

Participants

Reaction Steps

3-Amino-5-[(7-chloroquinolin-4-yl)amino]benzonitrile hydrochloride prepared from step B of example 19 (0.88 g, 2.98 mmol), 1-(2-chloroethyl)piperidine hydrochloride (0.55 g, 1 eq) and K2CO3 (0.83 g, 2 eq) were refluxed in 50 mL of acetonitrile for 48 h. The reaction mixture was then filtered. The filtrate was evaporated to yield expected compound as a yellow powder (0.58 g, 44% yield). m/z (ESI) 406.2 [M]+.

Provenance & Evidence