Piperidine, 1-(2-chloroethyl)-, hydrochloride → 3-Amino-5-{[2-(piperidin-1-yl)ethyl]amino}benzonitrile

Participants

Reaction Steps

3,5-Diaminobenzonitrile prepared from step A of example 19 (511 mg, 3.84 mmol), 1-(2-chloroethyl)piperidine hydrochloride (707 mg, 1 eq) and DIEA (1.97 mL, 3 eq) were refluxed in 50 mL of 2-methylbutan-1-ol for 24 h. The reaction mixture was then evaporated to give 751 mg of expected compound which was used in the next step without further purification. m/z (ESI) 245.3 [M+H]+.

Provenance & Evidence