HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,7-Dichloroquinoline → HCID 11382646, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,7-Dichloroquinoline | HCID 6866 | — |
| Reactant | HCID 19799804 | HCID 19799804 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 11382646 | HCID 11382646 | 42.6% |
Reaction Steps
5-amino-2-(pyrrolidin-1-ylmethyl)phenol (117 mg, 0.61 mmol) and 4,7-dichloroquinoline (143 mg, 1 eq) were refluxed overnight in 1 mL of EtOH. The reaction mixture was then evaporated and purified by flash chromatography (DCM/MeOH/NH4OH 9:1:0.1) to yield expected compound as a yellow solid (92 mg, 29% yield). LC-MS: m/z (ESI) 354.1-356.1 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680095B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-6b367161badb4c6283b90877dbd5b25e |
| Source note | uspto-grants-2014_03 |