Formaldehyde → HCID 53250974, compound

Participants

Reaction Steps

3-[(7-chloroquinolin-4-yl)amino]phenol (0.20 g, 0.74 mmol), formaldehyde 37% (62 μL, 1.1 eq), and N-methylpiperazine (90 μL, 1.1 eq) was dissolved in 1 mL of EtOH. The mixture was refluxed overnight, evaporated and purified by flash chromatography (DCM/MeOH/NH4OH 7.5:2.5:0.2) to yield expected compound as a pale yellow oil (42 mg, 15% yield). LC-MS: m/z (ESI) 383.3-385.3 [M+H]+

Provenance & Evidence