4,7-Dichloroquinoline → HCID 67247174, compound

Participants

Reaction Steps

[5-Amino-2-(morpholin-4-yl)phenyl]methanol (1.21 g, 5.80 mmol) and 4,7-dichloroquinoline (1.38 g, 6.98 mmol) were refluxed in 10 mL of n-pentanol for 3 h. The reaction mixture was then cooled to room temperature and the hydrochloride precipitate was removed by filtration to yield expected compound as a yellow powder (1.90 g, 80% yield). LC-MS: m/z (ESI) 370.3 [M+H]+.

Provenance & Evidence