Ethyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate → (4'-{4-[1-(2-Fluoro-4-methoxy-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-acetic acid ethyl ester

HRID 119092Notes

Reaction equation

HRID 119092 reaction equation
[CH2:29]([CH3:30])[O:31][C:32]([CH2:33][c:34]1[cH:35][cH:36][c:37]([B:40]2[O:41][C:42]([CH3:43])([CH3:44])[C:45]([CH3:46])([CH3:47])[O:48]2)[cH:38][cH:39]1)=[O:49].[F:1][c:2]1[c:3]([CH:10]([CH3:11])[O:12][C:13]([NH:14][c:15]2[c:16]([CH3:27])[n:17][o:18][c:19]2-[c:20]2[cH:21][cH:22][c:23]([Br:26])[cH:24][cH:25]2)=[O:28])[cH:4][cH:5][c:6]([O:8][CH3:9])[cH:7]1>>[F:1][c:2]1[c:3]([CH:10]([CH3:11])[O:12][C:13]([NH:14][c:15]2[c:16]([CH3:27])[n:17][o:18][c:19]2-[c:20]2[cH:21][cH:22][c:23](-[c:37]3[cH:36][cH:35][c:34]([CH2:33][C:32]([O:31][CH2:29][CH3:30])=[O:49])[cH:39][cH:38]3)[cH:24][cH:25]2)=[O:28])[cH:4][cH:5][c:6]([O:8][CH3:9])[cH:7]1

Participants

3

Reactant 2

HCID 46737998Ethyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetateHCID 67351863[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-carbamic acid 1-(2-fluoro-4-methoxy-phenyl)-ethyl ester

Product 1

HCID 67352883(4'-{4-[1-(2-Fluoro-4-methoxy-phenyl)-ethoxycarbonylamino]-3-methyl-isoxazol-5-yl}-biphenyl-4-yl)-acetic acid ethyl ester

Sources & evidence

ORD record
ord-32d3662da7e042119a3bed73642cab7e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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